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Article

Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS.

Nature medicine - 1 Feb 1997

Goulder P J, Phillips R E, Colbert R A, McAdam S, Ogg G, Nowak M A, Giangrande P, Luzzi G, Morgan B, Edwards A, McMichael A J, Rowland-Jones S

Abstract excerpt

The precise role played by HIV-specific cytotoxic T lymphocytes (CTL) in HIV infection remains controversial. Despite strong CTL responses being generated during the asymptomatic phase, the virus persists and AIDS ultimately develops. It has been argued that the virus is so variable, and the virus turnover so great that escape from CTL recognition would occur continually, but so far there is limited evidence for...

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Share to Acquired Immunodeficiency Syndrome
Share to Antigenic Variation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 9018241
DOI: 10.1038/nm0297-212

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS.PMID 9018241Read ↗

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Virus variation, escape from cytotoxic T lymphocytes and human retroviral persistence.Semantic proximity Read ↗

Structured observations reveal slow HIV-1 CTL escape.Semantic proximity Read ↗

Evolution of HIV‐1 in an HLA‐B*57–Positive Patient during Virologic EscapeSemantic proximity Read ↗

Immune escape precedes breakthrough human immunodeficiency virus type 1 viremia and broadening of the cytotoxic T-lymphocyte response in an HLA-B27-positive long-term-nonprogressing child.Semantic proximity Read ↗

Early evolution of human leucocyte antigen-associated escape mutations in variable Gag proteins predicts CD4+ decline in HIV-1 subtype C-infected women.Semantic proximity Read ↗

Epitope escape mutation and decay of human immunodeficiency virus type 1-specific CTL responses.Semantic proximity Read ↗

Kinetics of HIV-Specific CTL Responses Plays a Minimal Role in Determining HIV Escape DynamicsSemantic proximity Read ↗

Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA.Semantic proximity Read ↗

Cytotoxic T lymphocytes in asymptomatic long-term nonprogressing HIV-1 infection. Breadth and specificity of the response and relation to in vivo viral quasispecies in a person with prolonged infection and low viral load.Semantic proximity Read ↗

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