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Article

Huntington's disease transgenic mice are resistant to global cerebral ischemia.

Neuroscience letters - 13 Dec 2002

Schiefer Johannes, Alberty Anke, Dose Tatjana, Oliva Sabine, Noth Johannes, Kosinski Christoph M

Abstract excerpt

Excitotoxicity plays a key role in ischemic neuronal death and is also one of the candidate mechanisms contributing to neurodegeneration in Huntington's disease (HD). Unexpectedly we have now found that transgenic mice expressing exon 1 of a mutant human HD gene (R6/1) are protected against global cerebral ischemia (GCI), installed by temporary bilateral occlusion of the carotid arteries. Whereas wild type mice...

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Identifiers

PMID: 12435481
DOI: 10.1016/s0304-3940(02)01111-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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