Early NFkappaB activation is inhibited during focal cerebral ischemia in interleukin-1beta-converting enzyme deficient mice.

doi:10.1002/jnr.10654

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Article

Early NFkappaB activation is inhibited during focal cerebral ischemia in interleukin-1beta-converting enzyme deficient mice.

Journal of neuroscience research - 1 Sept 2003

Huang Feng-Peng, Wang Zhi-Qiu, Wu Du-Chu, Schielke Gerald P, Sun Yi, Yang Guo-Yuan

Abstract excerpt

Our previous study demonstrated that the inhibition of interleukin-1beta (IL-1beta) reduces ischemic brain injury; however, the molecular mechanism of the action of IL-1 in cerebral ischemia is unclear. We are investigating currently the role of NFkappaB during focal cerebral ischemia, using mutant mice deficient in the interleukin-1 converting enzyme gene (ICE KO) in a middle cerebral artery occlusion (MCAO)...

Topics

Animals
Blotting, Western
Brain
Brain Ischemia
Caspase 1
Electrophoretic Mobility Shift Assay
Immunohistochemistry
Infarction, Middle Cerebral Artery
Intercellular Adhesion Molecule-1
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Knockout

Mutation

NF-kappa B

Neurons

Phosphorylation

Protein Transport

Source

Open in PubMed

Identifiers

PMID: 12929137
DOI: 10.1002/jnr.10654

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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