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Article

Characterization of a glucose-repressed pyruvate kinase (Pyk2p) in Saccharomyces cerevisiae that is catalytically insensitive to fructose-1,6-bisphosphate.

Journal of bacteriology - 1 May 1997

Boles E, Schulte F, Miosga T, Freidel K, Schlüter E, Zimmermann F K, Hollenberg C P, Heinisch J J

Abstract excerpt

We have characterized the gene YOR347c of Saccharomyces cerevisiae and shown that it encodes a second functional pyruvate kinase isoenzyme, Pyk2p. Overexpression of the YOR347c/PYK2 gene on a multicopy vector restored growth on glucose of a yeast pyruvate kinase 1 (pyk1) mutant strain and could completely substitute for the PYK1-encoded enzymatic activity. PYK2 gene expression is subject to glucose repression. A...

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Identifiers

PMID: 9139918
DOI: 10.1128/jb.179.9.2987-2993.1997
PMCID: PMC179064

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