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Article

Molecular and functional characterization of two pyruvate decarboxylase genes, PDC1 and PDC5, in the thermotolerant yeast Kluyveromyces marxianus.

Applied microbiology and biotechnology - 1 Apr 2018

Choo Jin Ho, Han Changpyo, Lee Dong Wook, Sim Gyu Hun, Moon Hye Yun, Kim Jae-Young, Song Ji-Yoon, Kang Hyun Ah

Abstract excerpt

Pyruvate decarboxylase (Pdc) is a cytosolic enzyme located at the branch point between fermentative and respiratory sugar catabolism. Here, we identified and functionally characterized KmPDC1 and KmPDC5 encoding two homologs of Pdc in the thermotolerant yeast Kluyveromyces marxianus KCTC 17555. Despite the conservation of important Pdc domains, a few amino acid sequences essential for enzymatic activity are not...

Topics

Amino Acid Sequence
Fermentation
Fungal Proteins
Industrial Microbiology
Kluyveromyces
Mutation
Pyruvate Decarboxylase

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 29497799
DOI: 10.1007/s00253-018-8862-3

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