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Article

Novel human N-acetyltransferase 2 alleles that differ in mechanism for slow acetylator phenotype.

The Journal of biological chemistry - 3 Dec 1999

Leff M A, Fretland A J, Doll M A, Hein D W

Abstract excerpt

Three novel human NAT2 alleles (NAT2*5D, NAT2*6D, and NAT2*14G) were identified and characterized in a yeast expression system. The common rapid (NAT2*4) and slow (NAT2*5B) acetylator human NAT2 alleles were also characterized for comparison. The novel recombinant NAT2 allozymes catalyzed both N- and O-acetyltransferase activities at levels comparable with NAT2 5B and significantly below NAT2 4, suggesting that...

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Source

Identifiers

PMID: 10574910
DOI: 10.1074/jbc.274.49.34519

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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