Relationship between a low toxicity of the mutant A subunit of enterotoxigenic Escherichia coli enterotoxin and its strong adjuvant action.

doi:10.1046/j.1365-2567.1997.00156.x

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Article

Relationship between a low toxicity of the mutant A subunit of enterotoxigenic Escherichia coli enterotoxin and its strong adjuvant action.

Immunology - 1 Feb 1997

Tsuji T, Yokochi T, Kamiya H, Kawamoto Y, Miyama A, Asano Y

Abstract excerpt

In the work described here it was determined if and how unnicking in the A subunit of Escherichia coli enterotoxin at Arg192 or nearby residues affected biological activities of the toxin. The mutant toxin was constructed to lack the nick site in the A subunit by deleting the tripeptide Arg192-Th...

Topics

ADP Ribose Transferases
Adjuvants, Immunologic
Animals
Antibodies, Viral
Bacterial Toxins
Cyclic AMP
Diarrhea
Electrophoresis, Polyacrylamide Gel
Enterotoxins
Escherichia coli
Escherichia coli Proteins
Female
Immunoglobulin E
Immunoglobulin G
Measles virus
Mice
Mice, Inbred ICR
Mutation

Source

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Identifiers

PMID: 9135544
DOI: 10.1046/j.1365-2567.1997.00156.x
PMCID: PMC1456747

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9135544-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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