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RECOGNITION OF PORCINE MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I ANTIGENS BY HUMAN CD8+ CYTOLYTIC T CELL CLONES1

1 Jul 1997

Abstract excerpt

To evaluate the nature of the human cellular immune response to porcine xenoantigens, cytolytic T lymphocyte (CTL) cell lines were generated against porcine aortic endothelial cells (PAEC). After four stimulations, the phenotypes of the T cell lines were primarily CD8+ (79.7+/-19.6%). Natural killer cells were not detected. Functional analysis of the T cell lines showed specific cytotoxicity against syngeneic...

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PMID: 9256198
DOI: 10.1097/00007890-199707270-00028

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