In vitro selection of variants of herpes simplex virus type 1 which differ in cytopathic changes.

doi:10.1111/j.1348-0421.1997.tb01191.x

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Article

In vitro selection of variants of herpes simplex virus type 1 which differ in cytopathic changes.

Microbiology and immunology - 1 Jan 1997

Padilla J, Yamada M, Takahashi Y, Tsukazaki T, Nakamura J, Yoshida M, Uno F, Arao Y, Nii S

Abstract excerpt

To analyze the mechanisms for in vitro emergence of the syncytial variants of herpes simplex virus type 1 (HSV-1), several cell lines were infected with a mixture of equal amounts of two HSV-1 variants, one syncytial and the other non-syncytial, and changes in their relative abundance were monito...

Topics

Cell Line
Complement System Proteins
Cytopathogenic Effect, Viral
Genetic Variation
Giant Cells
Herpesvirus 1, Human
Interferon-beta
Selection, Genetic
Serial Passage
Viral Envelope Proteins

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