Article
Genotypic and phenotypic changes of BHK-21 cells grown in suspension cultures.
Cytotechnology - 1 Jan 1993
Amadori M, Berneri C
Abstract excerpt
The propagation of foot-and-mouth disease virus on BHK-21 suspension cells, although economically convenient, may yield a scarcely immunizing antigen. Helpful insights were obtained by investigating a few genotypic and phenotypic features of the cell cultures. The appearance of polyploid populations, higher cell concentrations at the end of culturing, the progressive reduction of spreading on surfaces and an...
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