Article
Identification of syncytial mutations in a clinical isolate of herpes simplex virus 2.
Virology - 25 Oct 2004
Muggeridge Martin I, Grantham Michael L, Johnson F Brent
Abstract excerpt
Small polykaryocytes resulting from cell fusion are found in herpes simplex virus (HSV) lesions in patients, but their significance for viral spread and pathogenesis is unclear. Although syncytial variants causing extensive fusion in tissue culture can be readily isolated from laboratory strains, they are rarely found in clinical isolates, suggesting that extensive cell fusion may be deleterious in vivo....
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