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Article

Antigen-specific induction of antibodies against native mammalian DNA in nonautoimmune mice.

1 Aug 1993

Abstract excerpt

Spontaneous anti-DNA antibodies in autoimmune mice have the characteristics of antibody produced by Ag-specific, clonally selective B cell stimulation. The nature of the somatically derived antibody V region structures recurrent among spontaneous anti-DNA antibodies suggests that DNA or DNA-protein complexes may provide the antigenic stimulus for autoimmune anti-DNA antibody. In order to test this hypothesis...

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PMID: 8393048
DOI: 10.4049/jimmunol.151.3.1614

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