Article
Mutation analysis of the coding sequences of MEK-1 and MEK-2 genes in human lung cancer cell lines.
Oncogene - 13 Mar 1997
Bansal A, Ramirez R D, Minna J D
Abstract excerpt
Recently, constitutively active mutants of MEK (MAP/ERK kinase) were shown to be capable of transforming cells to tumorigenicity suggesting that MEK can function as a dominant oncogene and potentially play a role in human carcinogenesis. Human lung cancer cells exhibit mutations in other components of the MAP kinase signaling pathway such as the Her-2/neu and ras oncogenes. Thus, the coding sequences of both...
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