Article
MAP2K1 (MEK1) Mutations Define a Distinct Subset of Lung Adenocarcinoma Associated with Smoking.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Apr 2015
Arcila Maria E, Drilon Alexander, Sylvester Brooke E, Lovly Christine M, Borsu Laetitia, Reva Boris, Kris Mark G, Solit David B, Ladanyi Marc
Abstract excerpt
PURPOSE: Genetic alterations affecting the MAPK/ERK pathway are common in lung adenocarcinoma (LAD). Early steps of the signaling pathway are most often affected with EGFR, KRAS, and BRAF mutations encompassing more than 70% of all alterations. Somatic mutations in MEK1, located downstream of BRAF, are rare and remain poorly defined as a distinct molecular subset. EXPERIMENTAL DESIGN: Tumors harboring MEK1...
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