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Article

Increase in constitutively active MEK1 species by introduction of MEK1 mutations identified in cancers.

Biochimica et biophysica acta. Proteins and proteomics - 1 Jan 2019

Kinoshita-Kikuta Emiko, Kinoshita Eiji, Ueda Sayaka, Ino Yoko, Kimura Yayoi, Hirano Hisashi, Koike Tohru

Abstract excerpt

The kinase MEK1 is an essential component of the mitogen-activated protein kinase cascades. Somatic mutations that have been identified in the MEK1-coding gene generally enhance kinase activity. Consequently, MEK1 has attracted much interest as a target for cancer therapy to block the aberrant activity. By using Phos-tag affinity electrophoresis, we found that the introduction of mutations detected in certain...

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Identifiers

PMID: 29753091
DOI: 10.1016/j.bbapap.2018.05.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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