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Article

Position-dependent transcriptional regulation of the murine dihydrofolate reductase promoter by the E2F transactivation domain.

Molecular and cellular biology - 1 Apr 1997

Fry C J, Slansky J E, Farnham P J

Abstract excerpt

Activity of the dihydrofolate reductase (dhfr) promoter increases at the G1-S-phase boundary of the cell cycle. Mutations that abolish protein binding to an E2F element in the dhfr promoter also abolish the G1-S-phase increase in dhfr transcription, indicating that transcriptional regulation is mediated by the E2F family of proteins. To investigate the mechanism by which E2F regulates dhfr transcription, we moved...

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Identifiers

PMID: 9121444
DOI: 10.1128/MCB.17.4.1966
PMCID: PMC232043

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