The C-terminal 70 amino acids of the adenovirus E4-ORF6/7 protein are essential and sufficient for E2F complex formation.

doi:10.1093/nar/19.23.6579

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Article

The C-terminal 70 amino acids of the adenovirus E4-ORF6/7 protein are essential and sufficient for E2F complex formation.

Nucleic acids research - 11 Dec 1991

O'Connor R J, Hearing P

Abstract excerpt

E2F is a cellular transcription factor that binds to the adenovirus (Ad) E1A enhancer and E2aE promoter regions, to the cellular c-myc P2 and dihydrofolate reductase promoters, and to other viral and cellular regulatory regions. The binding activity of E2F to the Ad E2aE promoter is dramatically increased during an adenovirus infection (termed E2F induction). E2F induction is dependent on the expression of the...

Topics

Adenovirus Early Proteins
Adenoviruses, Human
Amino Acid Sequence
Base Sequence
Binding Sites
DNA, Viral
Enhancer Elements, Genetic
Exons
HeLa Cells
Humans
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Oncogene Proteins, Viral

Open Reading Frames

Promoter Regions, Genetic

Protein Biosynthesis

Transcription Factors

Transcriptional Activation

Source

Open in PubMed Open full text

Identifiers

PMID: 1836562
DOI: 10.1093/nar/19.23.6579
PMCID: PMC329223

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1836562-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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