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Article

p53 and MDM2 alterations in osteosarcomas

15 Apr 1997

Abstract excerpt

BACKGROUND: Alterations of the p53 gene and of MDM2, a gene coding for a p53 binding protein, have been implicated in the pathogenesis of osteosarcoma (OS). METHODS: To determine the frequency of alterations of the p53/MDM2 pathway in OS and their possible correlation with clinicopathologic features, MDM2 copy number and p53 protein levels were determined in a series of 83 samples of OS by quantitative Southern...

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PMID: 9118036
DOI: 10.1002/(sici)1097-0142(19970415)79:8<1541::aid-cncr15>3.0.co;2-y

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