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Article

Proteolytic processing and degradation of human presenilin-1 expressed in yeast.

Neuroscience letters - 17 Mar 2000

Song S, Ohba M, Saito Y, Honda T, Takashima A, Takahashi H

Abstract excerpt

Numerous mutations causing early-onset familial Alzheimer's disease have been identified in the presenilin-1 gene. Presenilin-1 protein is produced as a 47 kDa holoprotein and proteolytically processed to an N-terminal 28 kDa and a C-terminal 19 kDa fragments by unidentified presenilinase in mamm...

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PMID: 10713397
DOI: 10.1016/s0304-3940(00)00845-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10713397-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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