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Article

Endoproteolytic Processing and Stabilization of Wild-type and Mutant Presenilin

1 Sept 1997

Abstract excerpt

Presenilin 1 (PS1), mutated in pedigrees of early-onset familial Alzheimer's disease, is a polytopic integral membrane protein that is endoproteolytically cleaved into 27-kDa N-terminal and 17-kDa C-terminal fragments. Although these fragments are the principal PS1 species found in normal mammalian brain, the role of endoproteolysis in the maturation of PS1 has been unclear. The present study, which uses stably...

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PMID: 9305918
DOI: 10.1074/jbc.272.39.24536

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Endoproteolytic Processing and Stabilization of Wild-type and Mutant PresenilinPMID 9305918Read ↗

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C terminus of presenilin is required for overproduction of amyloidogenic Abeta42 through stabilization and endoproteolysis of presenilin.Semantic proximity Read ↗

Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis.Semantic proximity Read ↗

Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis.Semantic proximity Read ↗

Alzheimer's disease associated presenilin-1 holoprotein and its 18-20 kDa C-terminal fragment are death substrates for proteases of the caspase family.Semantic proximity Read ↗

Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain TissueSemantic proximity Read ↗

Characterization of human presenilin 1 using N-terminal specific monoclonal antibodies: Evidence that Alzheimer mutations affect proteolytic processing.Semantic proximity Read ↗

Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors.Semantic proximity Read ↗

Proteolytic processing and degradation of human presenilin-1 expressed in yeast.Semantic proximity Read ↗

Presenilin endoproteolysis is an intramolecular cleavage.Semantic proximity Read ↗

Endoproteolysis of Presenilin 1 and Accumulation of Processed Derivatives In VivoSemantic proximity Read ↗

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