Article
Presenilin-1 Maintains a Nine-Transmembrane Topology throughout the Secretory Pathway
15 Jul 2006
Abstract excerpt
Presenilin-1 is a polytopic membrane protein that assembles with nicastrin, PEN-2, and APH-1 into an active gamma-secretase complex required for intramembrane proteolysis of type I transmembrane proteins. Although essential for a correct understanding of structure-function relationships, its exact topology remains an issue of strong controversy. We revisited presenilin-1 topology by inserting glycosylation...
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