Dimerization of presenilin-1 in vivo: suggestion of novel regulatory mechanisms leading to higher order complexes.

doi:10.1016/s0006-291x(02)02984-4

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Article

Dimerization of presenilin-1 in vivo: suggestion of novel regulatory mechanisms leading to higher order complexes.

Biochemical and biophysical research communications - 31 Jan 2003

Hébert Sébastien S, Godin Chantal, Tomiyama Takami, Mori Hiroshi, Lévesque Georges

Abstract excerpt

A growing body of evidence indicates that presenilins could exist and be active as oligomeric complexes. Using yeast two-hybrid and cell culture analysis, we provide evidence that presenilin-1 (PS1) may self-oligomerize giving rise to specific full-length/full-length homodimers. When expressed in N2A and HEK239T cultured cells, full-length PS1-wt and 5(')myc-PS1-wt form specific homodimers corresponding to twice...

Topics

Animals
Cell Line
Dimerization
Humans
Macromolecular Substances
Membrane Proteins
Mice
Molecular Weight
Mutation
Presenilin-1
Protein Structure, Quaternary
Saccharomyces cerevisiae
Two-Hybrid System Techniques

Source

Open in PubMed

Identifiers

PMID: 12535650
DOI: 10.1016/s0006-291x(02)02984-4

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