Article
Enhanced expression of the human vacuolar H+-ATPase c subunit gene (ATP6L) in response to anticancer agents.
The Journal of biological chemistry - 27 Sept 2002
Torigoe Takayuki, Izumi Hiroto, Ishiguchi Hiroshi, Uramoto Hidetaka, Murakami Tadashi, Ise Tomoko, Yoshida Yoichiro, Tanabe Mizuho, Nomoto Minoru, Itoh Hideaki, Kohno Kimitoshi
Abstract excerpt
We have isolated two overlapping genomic clones that contain the 5'-terminal portion of the human vacuolar H(+)-ATPase c subunit (ATP6L) gene. The sequence preceding the transcription initiation site, which is GC-rich, contains four GC boxes and one Oct1-binding site, but there is no TATA box or CCAAT box. In vivo footprint analysis in human cancer cells shows that two GC boxes and the Oct1-binding site are...
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