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Article

Involvement of the MRE2 gene of yeast in formation of meiosis-specific double-strand breaks and crossover recombination through RNA splicing.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Jan 1997

Nakagawa T, Ogawa H

Abstract excerpt

BACKGROUND: The mre2 mutant of Saccharomyces cerevisiae is defective in meiotic recombination and produces inviable spores, but the sensitivities to DNA damaging agents, methyl methanesulphonate and ultraviolet light are not altered by the mutation. Mre2 has two copies of RNA recognition motif (RRM), suggesting its participation in RNA metabolism in meiosis. RESULTS: An amino acid substitution in the N-terminal...

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PMID: 9112441
DOI: 10.1046/j.1365-2443.1997.d01-283.x

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