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Article

The MRE4 gene encodes a novel protein kinase homologue required for meiotic recombination in Saccharomyces cerevisiae.

Nucleic acids research - 11 Feb 1992

Leem S H, Ogawa H

Abstract excerpt

The MRE4 gene was cloned by complementation of the defects of meiotic recombination and haploidization in an mre4-1 mutant. Disruption of MRE4 resulted in reduced meiotic recombination and spore inviability. The mre4 spore lethality can be suppressed by spo13, a mutation that causes cells to bypass the reductional division. Analysis of meiotic DNA extracted from the mre4 mutant cells revealed that double-strand...

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Identifiers

PMID: 1741279
DOI: 10.1093/nar/20.3.449
PMCID: PMC310407

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