Article
Mre11 mediates gene regulation in yeast spore development.
Genes & genetic systems - 1 Feb 2007
Kugou Kazuto, Sasanuma Hiroyuki, Matsumoto Kouji, Shirahige Katsuhiko, Ohta Kunihiro
Abstract excerpt
Mre11, together with Rad50 and Xrs2/NBS, plays pivotal roles in homologous recombination, repair of DNA double strand breaks (DSBs), activation of damage-induced checkpoint, and telomere maintenance. Here we demonstrate that the absence of Mre11 in yeast causes specific effects on regulation of a class of meiotic genes for spore development. Using DNA microarray assays to analyze yeast mutants defective for...
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