Article
The rat corpulent (cp) mutation maps to the same interval on (Pgm1-Glut1) rat chromosome 5 as the fatty (fa) mutation.
Obesity research - 1 Mar 1997
Kahle E B, Butz K G, Chua S C, Kershaw E E, Leibel R L, Fenger T W, Hansen C T, Michaelis O E
Abstract excerpt
The autosomal recessive obesity mutations fatty (fa) and corpulent (cp) arose in separate rat strains, 13M and Koletsky, respectively. By complementation analysis, the two mutations appear to be in the same gene. The somewhat different phenotypes of fa/fa and cp/cp animals probably reflect the fa...
Topics
- Adipose Tissue
- Alleles
- Animals
- Body Composition
- Chromosome Mapping
- DNA, Satellite
- Female
- Genes, Recessive
- Genetic Linkage
- Genotype
- Glucose Transporter Type 1
- Male
- Mice
- Monosaccharide Transport Proteins
- Mutation
- Obesity
- Phenotype
- Phosphoglucomutase