Article
Rat obesity gene fatty (fa) maps to chromosome 5: evidence for homology with the mouse gene diabetes (db).
Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 1991
Truett G E, Bahary N, Friedman J M, Leibel R L
Abstract excerpt
The autosomal recessive mutations fa (rat) and db (mouse) cause obesity syndromes that develop early and ultimately become severe. Although both fa/fa rats and db/db mice have been studied extensively as models of human obesity and diabetes, the molecular bases of these phenotypes remain unknown....
Topics
- Animals
- Base Sequence
- Chromosome Mapping
- Crosses, Genetic
- Diabetes Mellitus, Experimental
- Female
- Genes
- Genetic Linkage
- Genotype
- Male
- Mice
- Mice, Mutant Strains
- Molecular Sequence Data
- Obesity
- Oligonucleotide Probes
- Rats
- Rats, Mutant Strains
- Recombination, Genetic