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Article

Identification of intermediate steps in the conversion of a mutant prion protein to a scrapie-like form in cultured cells.

The Journal of biological chemistry - 25 Apr 1997

Daude N, Lehmann S, Harris D A

Abstract excerpt

The central causative event in infectious, familial, and sporadic forms of prion disease is thought to be a conformational change that converts the cellular isoform of the prion protein (PrPC) into the scrapie isoform (PrPSc) that is the primary constituent of infectious prion particles. To provide a model system for analyzing the mechanistic details of this critical transformation, we have previously prepared...

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PMID: 9111077
DOI: 10.1074/jbc.272.17.11604

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Identification of intermediate steps in the conversion of a mutant prion protein to a scrapie-like form in cultured cells.PMID 9111077Read ↗

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