Article
A wild-type prion protein does not acquire properties of the scrapie isoform when coexpressed with a mutant prion protein in cultured cells.
Brain research. Molecular brain research - 1 Dec 1997
Lehmann S, Daude N, Harris D A
Abstract excerpt
Inherited prion diseases are linked to autosomal dominant mutations in the gene that encodes the prion protein (PrP). These mutations are thought to induce PrP to undergo a conformational alteration that converts it to a pathogenic form designated PrP(Sc). In patients who are heterozygous for PrP mutations, the protein encoded by the wild-type allele might influence the conversion of the mutant protein to the...
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