Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cell biological studies of the prion protein.

Current issues in molecular biology - 1 Jan 1999

Harris D A

Abstract excerpt

Studying PrPC and PrPSc in cell culture systems is advantageous because such systems contain all the organelles, membranes, and molecular cofactors that are likely to play an important role in the biology of the proteins. Using cultured cells expressing PrPC, we have discovered that this isoform constitutively cycles between the cell surface and an endocytic compartment, a process that is mediated by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cells, Cultured
Share to Endocytosis
Share to Glycosylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Prion Diseases

Share to Protein Transport

Share to PrPC Proteins

Share to PrPSc Proteins

Source

Identifiers

PMID: 11475702

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cell biological studies of the prion protein.PMID 11475702Read ↗

Trafficking, turnover and membrane topology of PrP.Semantic proximity Read ↗

Insights into the physiological function of cellular prion protein.Semantic proximity Read ↗

Analysis of the interactions between HIV-1 and the cellular prion protein in a human cell line.Semantic proximity Read ↗

The multiple functions of PrPC in physiological, cancer, and neurodegenerative contextsSemantic proximity Read ↗

Conserved roles of the prion protein domains on subcellular localization and cell-cell adhesion.Semantic proximity Read ↗

Mutant prion proteins are partially retained in the endoplasmic reticulum.Semantic proximity Read ↗

Stimulation of PrP(C) retrograde transport toward the endoplasmic reticulum increases accumulation of PrP(Sc) in prion-infected cells.Semantic proximity Read ↗

PrPs: Proteins with a purpose: Lessons from the zebrafish.Semantic proximity Read ↗

Mutant prion protein-mediated aggregation of normal prion protein in the endoplasmic reticulum: implications for prion propagation and neurotoxicity.Semantic proximity Read ↗

Compartment-restricted biotinylation reveals novel features of prion protein metabolism in vivo.Semantic proximity Read ↗

Cellular prion protein acts as mediator of amyloid beta uptake by caveolin‐1 causing cellular dysfunctions in vitro and in vivoSemantic proximity Read ↗

Topics in prion cell biology.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.