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Article

Mutant and infectious prion proteins display common biochemical properties in cultured cells.

The Journal of biological chemistry - 19 Jan 1996

Lehmann S, Harris D A

Abstract excerpt

Prion diseases are unusual neurodegenerative disorders that can be both infectious and inherited. Both forms are hypothesized to result from a posttranslational structural alteration in the cell surface glycoprotein PrPc (cellular isoform of the prion protein) that converts it into the protease-resistant isoform PrPSc (scrapie isoform of the prion protein). However, a direct comparison of molecular events...

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PMID: 8576163
DOI: 10.1074/jbc.271.3.1633

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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