Article
Disease-associated F198S mutation increases the propensity of the recombinant prion protein for conformational conversion to scrapie-like form.
The Journal of biological chemistry - 13 Dec 2002
Vanik David L, Surewicz Witold K
Abstract excerpt
The critical step in the pathogenesis of transmissible spongiform encephalopathies (prion diseases) is the conversion of a cellular prion protein (PrP(c)) into a protease-resistant, beta-sheet rich form (PrP(Sc)). Although the disease transmission normally requires direct interaction between exogenous PrP(Sc) and endogenous PrP(C), the pathogenic process in hereditary prion diseases appears to develop...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.