Article
The insertion allele at the angiotensin I-converting enzyme gene locus is associated with insulin resistance.
Metabolism: clinical and experimental - 1 Apr 1997
Chiu K C, McCarthy J E
Abstract excerpt
Plasma angiotensin I-converting enzyme (ACE) levels are genetically predetermined and are correlated with a deletion (D) insertion (I) polymorphism at the ACE gene locus. A subset of diabetic patients are noted to have elevated ACE levels. Treatment with ACE inhibitors has been shown to improve insulin sensitivity in both diabetic and nondiabetic subjects. We examined the relationship of D/I polymorphism and...
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