Article
The insertion/deletion polymorphism of the ACE gene is related to insulin sensitivity in overweight women.
Diabetes care - 1 Sept 2001
Ryan A S, Nicklas B J, Berman D M, Ferrell R E
Abstract excerpt
OBJECTIVE: The ACE insertion/deletion (I/D) polymorphism has been identified as a genetic risk factor for coronary heart disease (CHD). The deletion (D) allele of the ACE gene may be associated with higher insulin sensitivity. Individuals who are homozygous for the DD allele have higher ACE levels and possibly more angiotensin II, which, when infused exogenously, causes an increase in insulin sensitivity. The...
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