Probing the calcium-induced conformational transition of troponin C with site-directed mutants.

doi:10.1038/345182a0

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Article

Probing the calcium-induced conformational transition of troponin C with site-directed mutants.

Nature - 10 May 1990

Fujimori K, Sorenson M, Herzberg O, Moult J, Reinach F C

Abstract excerpt

The contraction of skeletal muscle is regulated by calcium binding to troponin C (TnC). TnC consists of two spatially independent domains, each of which contains two metal ion binding sites. Calcium binding to the regulatory sites of the N-terminal domain triggers muscle contraction by a series o...

Topics

Animals
Binding Sites
Calcium
Chickens
Crystallization
Escherichia coli
Hydrogen-Ion Concentration
Molecular Structure
Muscle Contraction
Muscles
Mutation
Protein Conformation
Rabbits
Recombinant Proteins
Signal Transduction
Structure-Activity Relationship
Troponin
Troponin C

Source

Open in PubMed

Identifiers

PMID: 2186281
DOI: 10.1038/345182a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2186281-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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