Article
The ABL genes in normal and abnormal cell development.
Critical reviews in oncogenesis - 1 Jan 1996
Chung S W, Daniel R, Wong B Y, Wong P M
Abstract excerpt
Genetic alteration of the c-abl protooncogene has led to abnormal cellular development, primarily within the hemopoietic system. Different forms of oncogenic alteration have variations in biological strength for cellular transformation. The abnormal Abl oncoproteins are known to suppress apoptosis, which may be the basis for causing leukemia development. However, recent evidence also shows that c-abl...
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