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Article

Role of mammalian Rad54 in telomere length maintenance.

Molecular and cellular biology - 1 Aug 2003

Jaco Isabel, Muñoz Purificación, Goytisolo Fermín, Wesoly Joanna, Bailey Susan, Taccioli Guillermo, Blasco María A

Abstract excerpt

The homologous recombination (HR) DNA repair pathway participates in telomere length maintenance in yeast but its putative role at mammalian telomeres is unknown. Mammalian Rad54 is part of the HR machinery, and Rad54-deficient mice show a reduced HR capability. Here, we show that Rad54-deficient mice also show significantly shorter telomeres than wild-type controls, indicating that Rad54 activity plays an...

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Share to Chromosome Aberrations
Share to DNA Helicases
Share to DNA Repair

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Repair Enzymes

Share to In Situ Hybridization, Fluorescence

Share to Recombination, Genetic

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Source

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Identifiers

PMID: 12897131
DOI: 10.1128/MCB.23.16.5572-5580.2003
PMCID: PMC166323

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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