Article
Partial enzymatic degradation of stroma allows enrichment and expansion of primary breast tumor cells.
Cancer research - 15 Apr 1997
Dairkee S H, Paulo E C, Traquina P, Moore D H, Ljung B M, Smith H S
Abstract excerpt
The goal of this study was to isolate and expand tumor cells in culture that closely resemble invasive cells in primary breast carcinoma tissue. Based on the hypothesis that invasive tumor cells are released more readily upon digestion with connective tissue-degrading enzymes because they are not confined within a basement membrane, we have designed a novel procedure for their isolation. Using this method, we...
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