Article
Immortalization and characterization of bone marrow stromal fibroblasts from a patient with a loss of function mutation in the estrogen receptor-alpha gene.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Apr 1998
Dieudonné S C, Xu T, Chou J Y, Kuznetsov S A, Satomura K, Mankani M, Fedarko N S, Smith E P, Robey P G, Young M F
Abstract excerpt
A male patient with abnormal postpubertal bone elongation was shown earlier to have a mutation in both alleles of the estrogen receptor, resulting in a nonfunctional gene. Marrow stromal fibroblasts (MSFs) derived from this patient were called HERKOs (human estrogen receptor knock outs), and in o...
Topics
- Adult
- Alleles
- Animals
- Bone Development
- Bone Marrow Cells
- Cell Division
- Cell Line
- DNA, Complementary
- Fibroblasts
- Hematopoiesis
- Humans
- Insulin-Like Growth Factor I
- Interleukin-6
- Male