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Article

Evidence for the GluR6 gene associated with younger onset age of Huntington's disease.

Neurology - 12 Oct 1999

MacDonald M E, Vonsattel J P, Shrinidhi J, Couropmitree N N, Cupples L A, Bird E D, Gusella J F, Myers R H

Abstract excerpt

Huntington's disease (HD) is attributed to a triplet CAG repeat mutation, and about half of the variation in onset age can be explained by the size of the repeat expansion. Recently, a TAA repeat polymorphism in close linkage to the kainate receptor, GluR6, was reported related to onset age in HD. We examined this polymorphism in 258 unrelated HD-affected persons (172 from a clinic sample and 86 from a postmortem...

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Source

Identifiers

PMID: 10522893
DOI: 10.1212/wnl.53.6.1330

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 11 closest

Evidence for the GluR6 gene associated with younger onset age of Huntington's disease.PMID 10522893Read ↗

Genotypes at the GluR6 kainate receptor locus are associated with variation in the age of onset of Huntington disease.Semantic proximity Read ↗

Experimental basis for the putative role of GluR6/kainate glutamate receptor subunit in Huntington's disease natural history.Semantic proximity Read ↗

TAA repeat variation in the GRIK2 gene does not influence age at onset in Huntington's disease.Semantic proximity Read ↗

Modulation of age at onset in Huntington's disease and spinocerebellar ataxia type 2 patients originated from eastern India.Semantic proximity Read ↗

NR2A and NR2B receptor gene variations modify age at onset in Huntington disease.Semantic proximity Read ↗

Association between BDNF Val66Met polymorphism and age at onset in Huntington disease.Semantic proximity Read ↗

NR2A and NR2B receptor gene variations modify age at onset in Huntington disease in a sex-specific manner.Semantic proximity Read ↗

Age at onset in Huntington's disease: replication study on the associations of ADORA2A, HAP1 and OGG1.Semantic proximity Read ↗

A genetic variation in the ADORA2A gene modifies age at onset in Huntington's disease.Semantic proximity Read ↗

Age at onset of Huntington disease is not modulated by the R72P variation in TP53 and the R196K variation in the gene coding for the human caspase activated DNase (hCAD).Semantic proximity Read ↗

Incorporating age at onset information into the transmission/disequilibrium test.Semantic proximity Read ↗

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