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Article

An engineered allosteric switch in leucine-zipper oligomerization.

Nature structural biology - 1 Jun 1996

Gonzalez L, Plecs J J, Alber T

Abstract excerpt

Controversy remains about the role of core side-chain packing in specifying protein structure. To investigate the influence of core packing on the oligomeric structure of a coiled coil, we engineered a GCN4 leucine zipper mutant that switches from two to three strands upon binding the hydrophobic ligands cyclohexane and benzene. In solution these ligands increased the apparent thermal stability and the...

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PMID: 8646536
DOI: 10.1038/nsb0696-510

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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