Article
HIV-1-encoded antisense RNA suppresses viral replication for a prolonged period.
Retrovirology - 8 May 2012
Kobayashi-Ishihara Mie, Yamagishi Makoto, Hara Takuma, Matsuda Yuka, Takahashi Ryutaro, Miyake Ariko, Nakano Kazumi, Yamochi Tadanori, Ishida Takaomi, Watanabe Toshiki
Abstract excerpt
BACKGROUND: Recent evidence proposes a novel concept that mammalian natural antisense RNAs play important roles in cellular homeostasis by regulating the expression of several genes. Identification and characterization of retroviral antisense RNA would provide new insights into mechanisms of replication and pathogenesis. HIV-1 encoded-antisense RNAs have been reported, although their structures and functions...
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