Article
Cannabinoid receptor gene (CNR1): association with i.v. drug use.
Molecular psychiatry - 1 Mar 1997
Comings D E, Muhleman D, Gade R, Johnson P, Verde R, Saucier G, MacMurray J
Abstract excerpt
The receptors for tetrahydrocannabinol, the active ingredient of marijuana, have been identified. A microsatellite polymorphism (AAT)n at the cannabinoid CB1 (brain) receptor gene (CNR1) consists of 9 alleles. Since the cannabinoid system is part of the reward pathway we examined the hypothesis that genetic variants of the CNR1 gene might be associated with susceptibility to alcohol or drug dependence. The study...
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