Article
Emergence of constitutively active estrogen receptor-α mutations in pretreated advanced estrogen receptor-positive breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2014
Jeselsohn Rinath, Yelensky Roman, Buchwalter Gilles, Frampton Garrett, Meric-Bernstam Funda, Gonzalez-Angulo Ana Maria, Ferrer-Lozano Jaime, Perez-Fidalgo Jose A, Cristofanilli Massimo, Gómez Henry, Arteaga Carlos L, Giltnane Jennifer, Balko Justin M, Cronin Maureen T, Jarosz Mirna, Sun James, Hawryluk Matthew, Lipson Doron, Otto Geoff, Ross Jeffrey S, Dvir Addie, Soussan-Gutman Lior, Wolf Ido, Rubinek Tamar, Gilmore Lauren, Schnitt Stuart, Come Steven E, Pusztai Lajos, Stephens Philip, Brown Myles, Miller Vincent A
Abstract excerpt
PURPOSE: We undertook this study to determine the prevalence of estrogen receptor (ER) α (ESR1) mutations throughout the natural history of hormone-dependent breast cancer and to delineate the functional roles of the most commonly detected alterations. EXPERIMENTAL DESIGN: We studied a total of 249 tumor specimens from 208 patients. The specimens include 134 ER-positive (ER(+)/HER2(-)) and, as controls, 115...
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