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Effect of 3 NR3C1 Mutations in the Pathogenesis of Pituitary ACTH Adenoma

24 Aug 2021

Abstract excerpt

CONTEXT: Glucocorticoids act through the glucocorticoid receptor (GR) encoded by the nuclear receptor subfamily 3 group C member 1 (NR3C1) gene. OBJECTIVE: This study aimed to examine the function of NR3C1 variants and their possible pathogenic role in Cushing disease (CD). METHODS: Next-generation sequencing was conducted in 49 CD patients. Corticotroph tumor GR protein expression was examined by...

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Share to Adrenal and Paraganglionic Tumors
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34427636
DOI: 10.1210/endocr/bqab167

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