Article
Cushing's disease preceded by generalized glucocorticoid resistance: clinical consequences of a novel, dominant-negative glucocorticoid receptor mutation.
Proceedings of the Association of American Physicians - 1 Jul 1996
Karl M, Lamberts S W, Koper J W, Katz D A, Huizenga N E, Kino T, Haddad B R, Hughes M R, Chrousos G P
Abstract excerpt
Generalized glucocorticoid resistance is associated with chronic hyperactivation of the hypothalamic-pituitary-adrenal axis, compensating for impaired glucocorticoid receptor function. We report a unique patient with sporadic generalized glucocorticoid resistance who, at age 33, presented with infertility and hypertension and, at 38, developed pituitary Cushing's disease. Leukocyte-binding studies revealed normal...
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