Article
Characterization of a complex glucocorticoid response unit in the phosphoenolpyruvate carboxykinase gene.
Molecular and cellular biology - 1 Sept 1990
Imai E, Stromstedt P E, Quinn P G, Carlstedt-Duke J, Gustafsson J A, Granner D K
Abstract excerpt
The minimal DNA sequence required for glucocorticoid induction of the phosphoenolpyruvate carboxykinase (PEPCK) gene in H4IIE rat hepatoma cells was defined. This novel glucocorticoid response unit (GRU) spans about 110 base pairs (bp) and includes two receptor-binding elements plus two accessory...
Topics
- Animals
- Base Sequence
- Cell Line
- Cell Nucleus
- Chloramphenicol O-Acetyltransferase
- Chromosome Deletion
- Dexamethasone
- Gene Expression Regulation, Enzymologic
- Liver
- Liver Neoplasms, Experimental
- Molecular Sequence Data
- Mutation
- Phosphoenolpyruvate Carboxykinase (GTP)
- Promoter Regions, Genetic