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Article

Activation of the phosphoenolpyruvate carboxykinase gene retinoic acid response element is dependent on a retinoic acid receptor/coregulator complex.

Molecular and cellular biology - 1 Dec 1992

Hall R K, Scott D K, Noisin E L, Lucas P C, Granner D K

Abstract excerpt

The accessory factor 1 (AF1) element is an upstream transcriptional control region that plays a role in the response of the phosphoenolpyruvate carboxykinase (PEPCK) gene to both glucocorticoids and retinoic acid. We demonstrate here that retinoic acid receptor alpha (RAR alpha) binds to a sequence within the AF1 element, TGACCT (site B), that is a consensus retinoic acid response element (RARE) half-site. A...

Topics

Base Sequence
Binding Sites
Binding, Competitive
Carrier Proteins
DNA
Enzyme Activation
Gene Expression Regulation, Enzymologic
Methylation
Molecular Sequence Data
Mutation
Phosphoenolpyruvate Carboxykinase (GTP)

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Plasmids

Receptors, Retinoic Acid

Regulatory Sequences, Nucleic Acid

Tretinoin

Source

Open in PubMed Open full text

Identifiers

PMID: 1333043
DOI: 10.1128/mcb.12.12.5527-5535.1992
PMCID: PMC360490

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1333043-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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