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Article

In vitro and in vivo evaluation of BO-2727 against imipenem- and/or meropenem-resistant Pseudomonas aeruginosa.

The Journal of antibiotics - 1 Feb 1997

Shibata K, Adachi Y, Kato E, Nagano R, Fuse A, Hashizume T, Ohtake N, Okamoto O, Nakagawa S

Abstract excerpt

The in vitro and in vivo activity of BO-2727, a carbapenem antibiotic, against resistant clinical isolates of Pseudomonas aeruginosa was studied. The geometric mean MICs against three groups of clinical isolates resistant to imipenem, meropenem and both carbapenems were 4.28, 4.08 and 5.44 microg...

Topics

Animals
Carbapenems
Ceftazidime
Cephalosporins
Culture Media
Drug Resistance, Microbial
Drug Resistance, Multiple
Humans
Imipenem
In Vitro Techniques
Male
Meropenem

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mutation

Pseudomonas Infections

Pseudomonas aeruginosa

Thienamycins

Source

Identifiers

PMID: 9099222
DOI: 10.7164/antibiotics.50.135

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9099222-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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